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体内转染Entranster™-in vivo

货号规格单价数量
18668-111ml¥2,599.00

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产品介绍

Entranster™-in vivo是英格恩生物公司（Engreen Biosystem Co,Ltd.）最新研发合成的用于动物体内转染的转染试剂。Entranster™-in vivo动物体内转染试剂可将小片断RNA如siRNA，miRNA，mimic、inhibitor转染到动物体内，在动物体内进行RNA干扰等实验。

Entranster™-in vivo试剂不是病毒，改变了病毒转染方法复杂、周期长、不稳定、花费大、安全性等诸多问题。Entranster™-in vivo转染效率高，方法简单，无需病毒包装，直接将RNA送入目的细胞的细胞核中表达。

Entranster™-in vivo，非脂质体，采用纳米技术合成，通过保护和浓缩核酸，避免核酸被体液破坏，并通过物理作用将核酸富集在细胞表面，增强核酸进入细胞组织，从而产生作用。Entranster™-in vivo能耐受体内复杂的环境，不产生免疫反应。

推荐应用范围

专用于动物体内转染，可直接转染RNA到动物体内进行：

● 基因治疗的动物体内研究

● RNA干扰的动物体内研究

● 蛋白功能的动物体内研究

 

主要特点

最快3天可以得到结果，核酸+转染试剂，注射动物，完成转染。

● 肝、肾、心、肺，血液系统，神经系统，生殖系统，皮肤…成功应用。

● 可方便、快捷更换不同的小片断RNA进行动物试验。

● 方法先进，抛弃病毒，众多实验室应用，稳定可靠。

● 比使用病毒节省90%以上费用，时间缩短到3天！

方法简单

如图所示，只需要将核酸和转染试剂分别稀释，混合，无需过滤，即可直接注射动物。

转染效果

将Entranster™-in vivo与Ambion in vivo siRNA(作用于凝血因子VII)和阴性siRNA通过尾静脉注射成年小鼠，2天后，取动物肝脏检测。在mRNA水平和蛋白水平观察干扰效果。见上图，图中最左侧组为对照组注射阴性siRNA为3mg/kg，后边3组为每kg动物注射阳性siRNA量分别为1mg/kg,2mg/kg和3mg/kg情况。

各器官转染

根据推荐用量注射Entranster™-in vivo和siRNA（作用于Lamin A/C）和阴性siRNA到成年小鼠。注射后2天收集相应的组织，分离RNA，用qRT-PCR分析Lamin A/C基因的表达水平。图4为尾静脉结果，图5为各器官分别局部注射结果。

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  58. Cell Rep. 2024 Sep 24;43(9):114691.doi: 10.1016/j.celrep.2024.114691. Epub 2024 Sep 3. Nogo-B inhibition facilitates cholesterol metabolism to reduce hypercholesterolemia (IF:8.8). Nogo-B抑制促进胆固醇代谢以降低高胆固醇血症

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  68. Nat Commun. 2024 Aug 10;15(1):6845.doi: 10.1038/s41467-024-51352-3. Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage (IF:14.700).肠Nogo-B通过与内质网上的胰高血糖素原结合来抑制PCSK1切割，从而降低GLP1水平

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  70. Int J Biol Sci. 2024 Jul 8;20(10):3842-3862.doi: 10.7150/ijbs.96262. eCollection 2024. Single-cell and Spatial Transcriptomics Reveals Ferroptosis as The Most Enriched Programmed Cell Death Process in Hemorrhage Stroke-induced Oligodendrocyte-mediated White Matter Injury (IF:10.750). 单细胞和空间转录组学揭示铁蛋白沉积是出血性卒中诱导的最丰富的程序性细胞死亡过程

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  73. Environ Toxicol. 2024 Jun;39(6):3548-3562.doi: 10.1002/tox.24197. Epub 2024 Mar 13. MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma 化学合成的华蟾毒素诱导的MiR-2110通过靶向FGFR1降低PTEN泛素化降解，发挥肿瘤转移抑制剂的作用

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  77. J Stroke Cerebrovasc Dis. 2024 May 18:107779.doi: 10.1016/j.jstrokecerebrovasdis.2024.107779. Online ahead of print. Function of miR-21-5p derived from ADSCs-exos on the neuroinflammation after cerebral ischemia ADSCs外泌体来源的miR-21-5p在脑缺血后神经炎症中的作用

  78. Mol Neurobiol. 2024 May 16.doi: 10.1007/s12035-024-04233-1. Online ahead of print. Mitochondrial Protein TAMM41 Modulates Depressive-like Behaviors 线粒体蛋白TAMM41调节抑郁行为

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  83. J Agric Food Chem. 2024 Apr 10.doi: 10.1021/acs.jafc.4c00059. Online ahead of print. The Impact of FBN1-α5β1 Axis in Fibro/Adipogenic Progenitor Cells (FAPCD9-) on Intramuscular Fat Content in Pigs 纤维/脂肪祖细胞（FAPCD9-）中FBN1-α5β1轴对猪肌内脂肪含量的影响

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  90. Cell Death Dis. 2024 Mar 7;15(3):193.doi: 10.1038/s41419-024-06579-9. TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits (IF:9). TREM2缺乏会损害施旺细胞的能量代谢，并加剧外周神经功能缺陷

  91. J Headache Pain. 2024 Mar 4;25(1):28.doi: 10.1186/s10194-024-01733-2. LncRNA Anxa10-203 enhances Mc1r mRNA stability to promote neuropathic pain by recruiting DHX30 in the trigeminal ganglion LncRNA-Anxa10-203通过在三叉神经节中募集DHX30来增强Mc1r mRNA的稳定性，从而促进神经性疼痛

  92. J Ethnopharmacol. 2024 Feb 16:326:117908.doi: 10.1016/j.jep.2024.117908. Online ahead of print. Quemeiteng granule relieves goiter by suppressing thyroid microvascular endothelial cell proliferation and angiogenesis via miR-217-5p-mediated targeting of FGF2-induced regulation of the ERK pathway 通过miR-217-5p介导的靶向FGF2诱导的ERK通路调节抑制甲状腺微血管内皮细胞增殖和血管生成，减轻甲状腺肿

  93. J Neurochem. 2024 Feb 13.doi: 10.1111/jnc.16075. Online ahead of print. Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy 三叉神经节circ_lrrc49减少通过下调Ist1和损害自噬导致小鼠神经性疼痛

  94. Mol Neurobiol. 2024 Feb;61(2):1023-1043.doi: 10.1007/s12035-023-03622-2. Epub 2023 Sep 7. Demethylase FTO-Mediated m6A Modification of lncRNA MEG3 Activates Neuronal Pyroptosis via NLRP3 Signaling in Cerebral Ischemic Stroke 去甲基化酶FTO介导的lncRNA MEG3的m6A修饰通过NLRP3信号激活缺血性脑卒中中的神经元

  95. CNS Neurosci Ther. 2024 Feb;30(2):e14400.doi: 10.1111/cns.14400. Epub 2023 Aug 24. Stromal cell-derived factor-1 downregulation contributes to neuroprotection mediated by CXC chemokine receptor 4 interactions after intracerebral hemorrhage in rats 大鼠脑出血后基质细胞衍生因子-1下调有助于CXC趋化因子受体4相互作用介导的神经保护作用

  96. Cell Death Dis. 2024 Feb 7;15(2):115.doi: 10.1038/s41419-024-06505-z. Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis HDAC4、PP1和GSDMD在控制焦下垂中的串扰 (IF:9).

  97. J Cell Physiol. 2024 Feb;239(2):e31159.doi: 10.1002/jcp.31159. Epub 2024 Jan 11. circUBE3C modulates myoblast development by binding to miR-191 and upregulating the expression of p27 circUBE3C通过与miR-191结合并上调p27的表达来调节成肌细胞的发育

  98. Int J Biol Macromol. 2024 Feb;257(Pt 2):128613.doi: 10.1016/j.ijbiomac.2023.128613. Epub 2023 Dec 8. Functionally conserved PPARG exonic circRNAs enhance intramuscular fat deposition by regulating PPARG and HSL 功能保守的PPARG外显子circRNAs通过调节PPARG和HSL增强肌内脂肪沉积

  99. Int J Biol Macromol. 2024 Jan;254(Pt 2):127824.doi: 10.1016/j.ijbiomac.2023.127824. Epub 2023 Nov 2. A novel lncRNA GM15416 regulates osteoblast apoptosis and differentiation through the c-Fos/Fas axis and mitigates osteoporosis 调节成骨细胞凋亡和分化，减轻骨质疏松症

  100. Gene. 2024 Jan 30:893:147945.doi: 10.1016/j.gene.2023.147945. Epub 2023 Oct 30. Cloning and characterization of heat shock transcription factor 1 and its functional role for Hsp70 production in the sea slug Onchidium reevesii 热休克转录因子1的克隆、鉴定及其在海蛞蝓Hsp70产生中的作用

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  103. Pharmacol Res. 2024 Jan:199:106990.doi: 10.1016/j.phrs.2023.106990. Epub 2023 Nov 18. A modified nucleoside O6-methyl-2′-deoxyguanosine-5′-triphosphate exhibits anti-glioblastoma activity in a caspase-independent manner 一种修饰的核苷O6-甲基-2′-脱氧鸟苷-5′-三磷酸以非胱天蛋白酶的方式显示抗胶质母细胞瘤活性 (IF:10.334).

  104. Int Immunopharmacol. 2024 Jan 25:127:111411.doi: 10.1016/j.intimp.2023.111411. Epub 2023 Dec 19. Spinal interleukin-16 mediates inflammatory pain via promoting glial activation 脊髓白细胞介素-16通过促进神经胶质细胞活化介导炎症性疼痛

  105. Respir Res. 2024 Jan 24;25(1):54.doi: 10.1186/s12931-024-02689-2. RUNX1 targeting AKT3 promotes alveolar hypercoagulation and fibrinolytic inhibition in LPS induced ARDS RUNX1通过NF-κB途径促进LPS诱导的大鼠ARDS肺泡高凝和纤溶抑制

  106. Adv Sci (Weinh). 2024 Jan;11(3):e2300702.doi: 10.1002/advs.202300702. Epub 2023 Nov 30. A Circular RNA Generated from Nebulin (NEB) Gene Splicing Promotes Skeletal Muscle Myogenesis in Cattle as Detected by a Multi-Omics Approach 应用多组学方法检测Nebulin（NEB）基因剪接产生的环状RNA促进牛骨骼肌肌生成 (IF:15.1).

  107. J Agric Food Chem. 2024 Jan 10;72(1):284-299.doi: 10.1021/acs.jafc.3c04406. Epub 2023 Dec 18. Low-Se Diet Increased Mitochondrial ROS to Suppress Myoblasts Proliferation and Promote Apoptosis in Broilers via miR-365-3p/SelT Signaling Axis 低硒饮食通过miR-365-3p/SelT信号轴增加线粒体ROS抑制肉鸡成肌细胞增殖和促进细胞凋亡

  108. J Gene Med. 2024 Jan;26(1):e3650.doi: 10.1002/jgm.3650. Epub 2023 Dec 7. Activation of toll-like receptor 4/nuclear factor-kappa B signaling by triggering a receptor expressed on myeloid cells 1 promotes alveolar macrophage M1 polarization and exacerbates septic acute lung injury 通过触发髓细胞上表达的受体激活toll样受体4/核因子κB信号传导1促进肺泡巨噬细胞M1极化

  109. J Biochem Mol Toxicol. 2024 Jan;38(1):e23617.doi: 10.1002/jbt.23617. Epub 2023 Dec 11. SNHG16/miR-205/HDAC5 is involved in the progression of renal fibrosis SNHG16/miR-205/HDAC5参与肾纤维化的进展

  110. Life Sci. 2024 Jan 1:336:122283.doi: 10.1016/j.lfs.2023.122283. Epub 2023 Nov 20. TET1-mediated epigenetic regulation of tumor necrosis factor-α in trigeminal ganglia contributes to chronic temporomandibular joint pain TET1介导的三叉神经节肿瘤坏死因子-α表观遗传学调控与慢性颞下颌关节疼痛的关系

  111. Epigenetics. 2023 Dec;18(1):2237789.doi: 10.1080/15592294.2023.2237789. MYOD induced lnc-MEG3 promotes porcine satellite cell differentiation via interacting with DLST MYOD诱导的lnc-MEG3通过与DLST相互作用促进猪卫星细胞分化

  112. Int J Mol Med. 2023 Dec;52(6):119.doi: 10.3892/ijmm.2023.5322. Epub 2023 Oct 27. Potential mechanism of TMEM2/CD44 in endoplasmic reticulum stress‑induced neuronal apoptosis in a rat model of traumatic brain injury TMEM2/CD44在大鼠创伤性脑损伤模型内质网应激诱导的神经元凋亡中的潜在机制

  113. Genes (Basel). 2023 Nov 9;14(11):2058.doi: 10.3390/genes14112058. rphologically Undifferentiated and Differentiated Gonads of Yangtze Sturgeon Acipenser dabryanus转录组分析揭示长江鲟形态未分化和分化性腺的表达谱

  114. Matrix Biol. 2023 Sep:122:33-45.doi: 10.1016/j.matbio.2023.08.001. Epub 2023 Aug 2. SIRT4 protects against intestinal fibrosis by facilitating GLS1 degradation SIRT4通过促进GLS1降解来预防肠纤维化

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  118. Neurochem Int. 2023 Jul;167:105553.doi: 10.1016/j.neuint.2023.105553. Epub 2023 May 23. Downregulation of Nogo-B ameliorates cerebral ischemia/reperfusion injury in mice through regulating microglia polarization via TLR4/NF-kappaB pathway (调节小胶质细胞极化改善小鼠脑缺血/再灌注损伤 )

  119. J Korean Neurosurg Soc . 2023 Jul;66(4):400-408. doi: 10.3340/jkns.2022.0115. Epub 2022 Oct 27. Nicotinamide Mononucleotide Adenylyl Transferase 2 Inhibition Aggravates Neurological Damage after Traumatic Brain Injury in a Rat Model

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  121. Curr Med Chem. 2023;30(22):2577-2589.doi: 10.2174/0929867329666221006111339. HDAC3 Impairs Cardiac Function in Chronic Heart Failure Rats via Mediating MicroRNA-26b-3p to Target High Mobility Group AT-Hook 2 通过介导MicroRNA-26b-3p靶向高迁移率组AT Hook 2影响慢性心力衰竭大鼠的心功能

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  313. Mol Med.2020 Nov 13;26(1):109.doi: 10.1186/s10020-020-00239-2.ZLM-7 inhibits the occurrence and angiogenesis of breast cancer through miR-212-3p/Sp1/VEGFA signal axisZLM-7通过miR-212-3p/Sp1/VEGFA信号轴抑制乳腺癌的发生和血管生成(IF:6.354).

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  320. Br J Pharmacol.2020 Aug;177(16):3760-3777.doi: 10.1111/bph.15099. Epub 2020 Jun 27.Astaxanthin attenuates hepatic damage and mitochondrial dysfunction in non-alcoholic fatty liver disease by up-regulating the FGF21/PGC-1α pathway.葡萄黄质通过上调FGF21/PGC-1α途径减轻非酒精性脂肪肝的肝损伤和线粒体功能障碍(IF:8.739).

  321. Theranostics.2020 Aug 29;10(24):10908-10924.doi: 10.7150/thno.48264. eCollection 2020.Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus. 环状RNAcircPPM1F调节M1巨噬细胞的活化和胰岛炎症(IF:11.556).

  322. Front Physiol. 2020; 11: 846. Published online 2020 Aug 11. doi: 10.3389/fphys.2020.00846PRDM16 Upregulation Induced by MicroRNA-448 Inhibition Alleviates Atherosclerosis via the TGF-β Signaling Pathway Inactivation

  323. Biochem Biophys Res Commun.2020 Nov 5;532(2):271279.doi:10.1016/j.bb rc.2020.06.142.Epub 2020 Aug 29.Suppressing BRD4 exhibits protective effects against vincristine-induced peripheral neuropathy by alleviating inflammation and oxidative stress

  324. Biomed Pharmacother.2020Aug;128:110045.doi:10.1016/j.biopha.2020.110 045.Epub 2020 May 24.Triad3A displays a critical role in suppression of cerebral ischemic/reperfusion (I/R) injury by regulating necroptosis Triad3A通过调节坏死性凋亡抑制脑缺血/再灌注（I/R）损伤过程中发挥关键作用

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  328. Theranostics. 2020; 10(18): 8430–8445.Published online 2020 Jul 9. doi: 10.7150/thno.44370Modulation of the Astrocyte-Neuron Lactate Shuttle System contributes to Neuroprotective action of Fibroblast Growth Factor 21(IF:11.556).

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    Source of dopamine in gastric juice and luminal dopamine‐induced duodenal bicarbonate secretion via apical dopamine D2 receptors胃液中多巴胺的来源及多巴胺诱导的十二指肠

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  337. Onco Targets Ther. 2020; 13: 3789–3800. Published online 2020 May 5. doi: 10.2147/OTT.S245346.miR-145 Inhibits Th9 Cell Differentiation by Suppressing Activation of the PI3K/Akt/mTOR/p70S6K/HIF-1α Pathway in Malignant Ascites from Liver Cancer.

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  341. Biochem Pharmacol.2020 Apr;174:113822.doi: 10.1016/j.bcp.2020.113822. Epub 2020 Jan 25.MicroRNA let-7g-5p alleviates murine collagen-induced arthritis by inhibiting Th17 cell differentiationMicroRNA let-7g-5p通过抑制Th17细胞分化减轻小鼠胶原诱导的关节炎

  342. Neurochem Int.2020 Mar;134:104656.doi: 10.1016/j.neuint.2019.104656. Epub 2019 Dec 31. Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C.

  343. Exp Cell Res.2020 Mar 1;388(1):111801.doi: 10.1016/j.yexcr.2019.111801.Epub 2019 Dec 23.Interleukin 9 prevents immune thrombocytopenia in mice via JAK/STAT5 signaling白细胞介素9通过JAK/STAT5信号通路预防小鼠免疫性血小板减少

  344. Mol Med Rep.2020 Mar;21(3):1145-1153.doi: 10.3892/mmr.2019.10903. Epub 2019 Dec 23.miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8.miR-222通过靶向ITGB8调节脑出血后的脑损伤和炎症

  345. Exp Ther Med. 2020 Mar;19(3):2029-2036.doi:10.3892/etm.2020.8456. Epub 2020 Jan 15.Effect of AQP4-RNAi in treating traumatic brain edema: Multi-modal MRI and histopathological changes of early stage edema in a rat modelAQP4 RNAi在治疗创伤性脑水肿中的作用：大鼠模型早期水肿的多模式MRI和组织病理学变化

  346. Biochem Biophys Res Commun. 2020 Mar 19;523(4):931-938.doi:10.1016/j.bbrc.2020.01.029. Epub 2020 Jan 18. Inhibition of miR-200b-3p alleviates hypoxia-ischemic brain damage via targeting Slit2 in neonatal rats减轻缺氧缺血性脑损伤

  347. Biomed Pharmacother. 2020 Mar;123:109761.doi:10.1016/j.biopha.2019.109761. Epub 2019 Dec 19. CRBN knockdown mitigates lipopolysaccharide-induced acute lung injury by suppression of oxidative stress and endoplasmic reticulum (ER) stress associated NF-κB signalingCRBN基因敲除减轻脂多糖诱导的急性肺损伤

  348. Mol Med Rep. 2020 Feb;21(2):795-805.doi: 10.3892/mmr.2019.10870.Epub 2019 Dec 6.BAFF is involved in the pathogenesis of IgA nephropathy by activating the TRAF6/NF‑κB signaling pathway in glomerular mesangial cells.BAFF通过激活肾小球系膜细胞中的TRAF6/NF-κB信号通路参与IgA肾病的发病机制

  349. Int J Biol Sci. 2020 Feb 21;16(8):1417-1426.doi: 10.7150/ijbs.42019. eCollection 2020. miR-197-3p Represses the Proliferation of Prostate Cancer by Regulating the VDAC1/AKT/β-catenin Signaling Axis miR-197-3p通过调节VDAC1/AKT/β-catenin信号轴抑制癌症前列腺增生 (IF:10.75).

  350. Anim Reprod Sci.2020 Apr;215:106332.doi: 10.1016/j.anireprosci.2020.106332.Epub 2020 Feb 25.Molecular characteristics and abundance of insulin-like androgenic gland hormone and effects of RNA interference in Eriocheir sinensis

  351. Cell Prolif. 2020 Feb;53(2):e12744.doi: 10.1111/cpr.12744. Epub 2019 Dec 15. MLL1 promotes myogenesis by epigenetically regulating Myf5肌肉注射

  352. Mol Ther Nucleic Acids.2020 Jun 5;20:292-307.doi: 10.1016/j.omtn.2019.12.027.Epub 2020 Jan 10.mmu_circ_0000790 Is Involved in Pulmonary Vascular Remodeling in Mice with HPH via MicroRNA-374c-Mediated FOXC1.mmu_circ_0000790通过MicroRNA-374c介导的FOXC1参与HPH小鼠肺血管重塑(IF:8.886).

  353. Biochem Biophys Res Commun. 2020 Jan 15;521(3):569-576.doi:10.1016/j.bbrc.2019.09.111. Epub 2019 Oct 31. Progranulin protects against cerebral ischemia-reperfusion (I/R) injury by inhibiting necroptosis and oxidative stress脑缺血再灌注损伤

  354. Cell Transplant. 2020 Jan-Dec:29:963689720950226.doi: 10.1177/0963689720950226. 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase Suppresses Neuronal Apoptosis by Increasing Glycolysis and “cyclin-dependent kinase 1-Mediated Phosphorylation of p27 After Traumatic Spinal Cord Injury in Rats 通过增加糖酵解和“细胞周期蛋白依赖性激酶1-介导的p27磷酸化抑制大鼠脊髓创伤后神经元凋亡

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  356. Oxid Med Cell Longev.2019 Dec 24;2019:7838754.doi: 10.1155/2019/7838754.eCollection 2019.IGF1 Knockdown Hinders Myocardial Development through Energy Metabolism Dysfunction Caused by ROS-Dependent FOXO Activation in the Chicken Heart.(IF:6.543).

  357. Bone Joint Res. 2019 Dec 3;8(11):550-562.doi: 10.1302/2046-3758.811.BJR-2018-0251.R1. eCollection 2019 Nov.MicroRNA-186 improves fracture healing through activating the bone morphogenetic protein signalling pathway by inhibiting SMAD6 in a mouse model of femoral fracture: An animal study.在小鼠股骨骨折模型中，MicroRNA-186通过抑制SMAD6,激活骨形态蛋白信号通路，从而促进骨折愈合：一项动物研究.(IF:5.853).

  358. Mol Brain.2019 Dec 3;12(1):102.doi: 10.1186/s13041-019-0523-7. Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1.沉默microRNA-146a使Notch-1表达降低从而减轻颞叶癫痫的神经损伤。

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    lnc-3215 Suppression Leads to Calcium Overload in Selenium Deficiency-Induced Chicken Heart Lesion via the lnc-3215-miR-1594-TNN2 Pathway （lnc-3215与低硒鸡心脏损伤钙超载研究）

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    Activation of Dusp14 protects against osteoclast generation and bone loss by regulating AMPKα-dependent manner（破骨细胞生成和骨丢失研究）

  362. Front Psychiatry . 2019 Oct 18;10:770. doi: 10.3389/fpsyt.2019.00770. eCollection 2019.Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X 7 Receptor

  363. World Neurosurg. 2019 Oct;130:e54-e61. doi: 10.1016/j.wneu.2019.05.194. Epub 2019 May 29.erebral Ischemia/Reperfusion Injury in Stroke Patients and a Mouse Model.

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    Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats（mfhas1对脓毒症大鼠认知功能障碍及海马树突病理的影响研究）

  365. Mol Ther Nucleic Acids.2019 Sep 6;17:891-906.doi: 10.1016/j.omtn.2019.07.017.Epub 2019 Aug 1.Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide.使用改良细胞穿透肽在完整角膜上皮中能够有效地局部递送siRNA实现基因沉默(IF:8.886).

  366. Exp Neurol. 2019 Nov;321:113028. doi: 10.1016/j.expneurol.2019.113028. Epub 2019 Aug 1.Botch protects neurons from ischemic insult by antagonizing Notch-mediated neuroinflammation.Botch通过拮抗Notch介导的神经炎症保护神经元免受缺血损伤(IF:5.330).

  367. Neurobiol Dis.2019 Sep;129:144-158. doi: 10.1016/j.nbd.2019.05.004.
    RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis（RIP3与大鼠实验性蛛网膜下腔出血后早期脑损伤研究）

  368. Biosci Rep.2019 Sep 9;39(9):BSR20190432.doi: 10.1042/BSR20190432. Print 2019 Sep 30. Extracellular regulated kinase 5 mediates osteoporosis through modulating viability and apoptosis of osteoblasts in ovariectomized rats.细胞外调节激酶5通过调节去卵巢大鼠成骨细胞的活力和凋亡介导骨质疏松.

  369. Life Sci.2019 Nov 15;237:116769.doi: 10.1016/j.lfs.2019.116769.Epub 2019 Aug 15.LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1.

  370. Biomed Pharmacother.2019 Sep;117:109155.doi: 10.1016/j.biopha.2019.109155.Epub 2019 Jul 1.CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress.CFLAR通过调节炎症和内质网应激，成为脑缺血再灌注损伤的重要调节因子(IF:6.529).

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    Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction.（肝胰高血糖素反应研究）

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  374. Biochem Biophys Res Commun.2019 Aug 6;515(4):651-657.doi: 10.1016/j.bbrc.2019.05.065.Epub 2019 Jun 6.eperfusion injury through regulating apoptosis and inflammation. Trim47可以调节细胞凋亡和炎症，是脑缺血再灌注损伤的关键调节因子

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    Advanced oxidation protein products induce G1 phase arrest in intestinal epithelial cells via a RAGE/CD36-JNK-p27kip1 mediated pathway（肠上皮细胞G1期阻滞研究）

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    Regulation of response to radiotherapy by β-arrestin1 in Non-small cell lung cancer（非小细胞肺癌研究）

  378. Brain Res Bull.2019 Jul;149:216-221.doi:10.1016/j.brainresbull.2019.04.024.Epub 2019 Apr 30. bnormal sympathetic activity after myocardial ischemia involving P2X4 in dorsal root ganglia.

  379. Biochem Biophys Res Commun .2019 Jun 25;514(2):558-564. doi: 10.1016/j.bbrc.2019.04.086.
    FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK（FBXW5与脊髓损伤研究）

  380. Cell Transplant.2019 Jun;28(6):723-738.doi: 10.1177/0963689718817219. Epub 2018 Dec 4.Detrimental Role of miRNA-144-3p in Intracerebral Hemorrhage Induced Secondary Brain Injury is Mediated by Formyl Peptide Receptor 2 Downregulation Both In Vivo and In Vitro.脑出血诱导的继发性脑损伤中的有害作用

  381. J Cell Physiol . 2019 Jul;234(7):11524-11536. doi: 10.1002/jcp.27815.
    A novel long noncoding RNA AK016739 inhibits osteoblast differentiation and bone formation（LncRNA AK016739抑制成骨细胞分化和骨形成）

  382. Osteoarthritis Cartilage . 2019 Jun;27(6):922-931. doi:10.1016/j.joca.2019.01.012.
    Clock mutant promotes osteoarthritis by inhibiting the acetylation of NFκB（Clock突变体和骨关节炎研究）

  383. EBioMedicine.2019 Jun;44:439-451. doi: 10.1016/j.ebiom.2019.05.041
    MicroRNA-200b is downregulated and suppresses metastasis by targeting LAMA4 in renal cell carcinoma（microrna-200b与肾癌转移研究）

  384. Neuroscience . 2019 Jun 15;409:43-57. doi: 10.1016/j.neuroscience.2019.04.041.
    NEMO-binding domain peptides alleviate perihematomal inflammation injury after experimental intracerebral hemorrhage（实验性脑出血后血周炎症损伤研究）

  385. Cell Death Dis.2019 Jun 5;10(6):441. doi: 10.1038/s41419-019-1631-0.
    Mechanism of Snhg8/miR-384/Hoxa13/FAM3A axis regulating neuronal apoptosis in ischemic mice model（缺血小鼠神经元凋亡调控研究）

  386. Aging (Albany NY).2019 May 7;11(9):2762-2786.doi: 10.18632/aging.101948.MiR-191 inhibit angiogenesis after acute ischemic stroke targeting VEZF1.

  387. Cell Tissue Res.2019 Oct;378(1):67-80.doi: 10.1007/s00441-019-03026-6.Epub 2019 May 18.Interference of miR-943-3p with secreted frizzled-related proteins4 (SFRP4) in an asthma mouse model.miR-943-3p对哮喘小鼠模型分泌型卷曲相关蛋白4（SFRP4）的干扰作用.(IF:5.249).

  388. Brain Behav Immun . 2019 May;78:188-201. doi: 10.1016/j.bbi.2019.01.020
    MicroRNA-146a protects against cognitive decline induced by surgical trauma by suppressing hippocampal neuroinflammation in mice（小鼠手术创伤引起的认知功能下降研究）

  389. Exp Neurol . 2019 May;315:21-31. doi:10.1016/j.expneurol.2019.01.018.

    GATA-4 regulates neuronal apoptosis after intracerebral hemorrhage via the NF-κB/Bax/Caspase-3 pathway both in vivo and in vitro（GATA-4调节脑出血后神经元凋亡）

  390. J Am Heart Assoc. 2019 May 7;8(9):e011851.doi: 10.1161/JAHA.118.011851.el Role of Carbon Monoxide in Improving Neurological Outcome After Cardiac Arrest in Aged Rats: Involvement of Inducing Mitochondrial Autophagy.一氧化碳在改善老年大鼠心脏骤停后神经功能方面的新作用：参与诱导线粒体自噬

  391. J Mol Neurosci.2019 May;68(1):144-152.doi: 10.1007/s12031-019-01293-0.Epub 2019 Mar 20.Neuroprotective Influence of miR-301a Inhibition in Experimental Cerebral Ischemia/Reperfusion Rat Models Through Targeting NDRG2.

  392. Cell Mol Immunol . 2019 May;16(5):483-494. doi: 10.1038/s41423-018-0033-z.
    Metabolic modulation of acetaminophen-induced hepatotoxicity by osteopontin（骨桥蛋白代谢对乙酰氨基酚肝毒性的调节作用研究）

  393. Bioconjug Chem . 2019 May 15;30(5):1459-1465. doi: 10.1021/acs.bioconjchem.9b00204.
    Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice（笼状siRNA和光化学调控RNAi诱导的小鼠基因沉默研究）

  394. FASEB J. 2019 Apr;33(4):5112-5125.doi: 10.1096/fj.201801111RR.Epub 2019 Jan 17.Long noncoding RNA AK089579 inhibits epithelial-to-mesenchymal transition of peritoneal mesothelial cells by competitively binding to microRNA-296-3p via DOK2 in peritoneal fibrosis.在腹膜纤维化中，长非编码RNA AK089579通过DOK2与microRNA-296-3p的竞争性结合抑制腹膜间皮细胞上皮向间充质转化.(IF:5.191).

  395. Exp Ther Med. 2019 Apr;17(4):3117-3123.doi: 10.3892/etm.2019.7322.Epub 2019 Feb 26.NL1 expression level in Nrx1β and the excitability of PV interneurons in mice with POCD.术后认知功能障碍小鼠NL1表达水平与小白蛋白的中间神经元兴奋性

  396. J Cell Physiol. 2019 Apr;234(4):3720-3729.doi: 10.1002/jcp.27146. Epub 2018 Oct 14.
    MiR-208b regulates cell cycle and promotes skeletal muscle cell proliferation by targeting CDKN1A （mir‐208b通过靶向cdkn1a调节细胞周期并促进骨骼肌细胞增殖）

  397. Free Radic Biol Med. 2019 Apr;134:23-41.doi: 10.1016/j.freeradbiomed.2018.12.034. Epub 2018 Dec 30.
    Loss of RIP3 initiates annihilation of high-fat diet initialized nonalcoholic hepatosteatosis: A mechanism involving Toll-like receptor 4 and oxidative stress（RIP3的缺失和非酒精性脂肪肝疾病研究）(IF:6.020).

  398. Am J Physiol Gastrointest Liver Physiol.2019 Apr 1;316(4):G539-G550. doi:10.1152/ajpgi.00249.2018.Epub 2019 Feb 8.lncRNA GAS5 restrains CCl 4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. lncRNA GAS5通过PTEN/PI3K/Akt信号通路靶向miR-23a，抑制CCl4诱导的肝纤维化。

  399. J Cell Biochem.2019 Mar;120(3):4238-4247.doi: 10.1002/jcb.27709.Epub 2018 Sep 30.Role of high-mobility group B1 in myocardial injury induced by coronary microembolization in rats高迁移率族B1在大鼠冠状动脉微栓塞心肌损伤中的作用

  400. J Cell Biochem. 2019 Mar;120(3):2847-2858.doi: 10.1002/jcb.26567. Epub 2018 Nov 30.
    Effects of microrna-93 on mouse cardiac microvascular endothelial cells injury and inflammatory response by mediating SPP1 through the NF-ΚB pathway （microRNA‐93与小鼠心肌微血管内皮细胞损伤研究）

  401. Dev Comp Immunol. 2019 Mar;92:150-159.doi: 10.1016/j.dci.2018.11.006. Epub 2018 Nov 11.
    Global profiling of megalocytivirus-induced proteins in tongue sole (Cynoglossus semilaevis) spleen identifies cellular processes essential to viral infection （半滑舌鳎脾脏巨核细胞病毒诱导蛋白）

  402. J Cell Biochem. 2019 Mar;120(3):2973-2982.doi: 10.1002/jcb.27025. Epub 2018 Dec 5.
    miR-202 modulates the progression of neuropathic pain through targeting RAP1A （Mir-202通过靶向RAP1A调节神经性疼痛的进展 ）

  403. Exp Neurol. 2019 Mar;313:37-48.doi: 10.1016/j.expneurol.2018.12.003. Epub 2018 Dec 5. Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury （大鼠脑外伤后大脑皮层环状RNA变化研究）(IF:4.483).

  404. Biomed Pharmacother.2019 Mar;111:468-475.doi: 10.1016/j.biopha.2018.12.105.Epub 2018 Dec 27.Kaempferol protects mice from d-GalN/LPS-induced acute liver failure by regulating the ER stress-Grp78-CHOP signaling pathway.山奈酚通过调节内质网应激-Grp78-CHOP信号通路保护d-GalN/LPS诱导的小鼠急性肝衰竭(IF:6.529).

  405. Front Cell Neurosci.2019 Mar 26;13:117.doi: 10.3389/fncel.2019.00117. eCollection 2019.Semaphorin 3A Contributes to Secondary Blood-Brain Barrier Damage After Traumatic Brain Injury.信号蛋白3A参与创伤性脑损伤后继发性血脑屏障损伤过程(IF:5.505).

  406. Immunol Lett. 2019 Feb;206:1-10.doi: 10.1016/j.imlet.2018.11.014. Epub 2018 Nov 29. miR-181b regulates ER stress induced neuron death through targeting Heat Shock Protein A5 following intracerebral haemorrhage.神经元死亡

  407. Front Mol Neurosci.2019 Feb 22;12:42.doi: 10.3389/fnmol.2019.00042. eCollection 2019. atrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury.苯甲酸钠通过Akt磷酸化和DJ-1相关抗氧化应激途径减轻大鼠创伤性脊髓损伤模型中的神经元凋亡

  408. Front Genet. 2019 Feb 19;10:112.doi: 10.3389/fgene.2019.00112. eCollection 2019. Wnt Signaling Pathway Linked to Intestinal Regeneration via Evolutionary Patterns and Gene Expression in the Sea Cucumber Apostichopus japonicus

  409. Anticancer Drugs 2019 Jan;30(1):38-45.doi: 10.1097/CAD.0000000000000687.Increased miR-203-3p and reduced miR-21-5p synergistically inhibit proliferation, migration, and invasion in esophageal cancer cells.增加miR-203-3p和减少miR-21-5p协同抑制食管癌细胞的增殖、迁移和侵袭。

  410. Biochem Biophys Res Commun. 2019 Jan 15;508(3):701-708.doi: 10.1016/j.bbrc.2018.11.072. Epub 2018 Dec 5.
    Blocking of tripartite motif 8 protects against lipopolysaccharide (LPS)-induced acute lung injury by regulating AMPKα activity （脂多糖（LPS）诱导的急性肺损伤）

  411. Br J Pharmacol. 2019 Feb;176(3):400-415.doi: 10.1111/bph.14537. Epub 2018 Dec 18. Mitochondrial protective effect of neferine through the modulation of nuclear factor erythroid 2-related factor 2 signalling in ischaemic stroke（荷花碱通过调节nrf2信号对缺血性卒中线粒体的保护作用 ）(IF:6.810).

  412. Int J Clin Exp Pathol.2019 Jun 1;12(6):2157-2165.eCollection 2019. nhibition of CLU4A exhibits a cardioprotective role in hypoxia/reoxygenation-induced injury by an ERK-dependent pathway.

  413. Biochem Biophys Res Commun.2019 Jun 25;514(2):550-557.doi: 10.1016/j.bbrc.2019.04.161.Epub 2019 May 3. Long non-coding RNA CHRF modulates the progression of cerebral ischemia/reperfusion injury via miR-126/SOX6 signaling pathway.长链非编码RNA CHRF通过miR-126/SOX6信号通路调节脑缺血/再灌注损伤的发展

  414. Mol Med Rep.2019 Jan;19(1):327-337.doi: 10.3892/mmr.2018.9640.Epub 2018 Nov 9. N‑terminal kinase inhibition attenuates early brain injury induced neuronal apoptosis via decreasing p53 phosphorylation and mitochondrial apoptotic pathway activation in subarachnoid hemorrhage rats.

  415. J Neuroinflammation . 2019 Jan 15;16(1):8. doi: 10.1186/s12974-019-1396-5.
    Mesenchymal stem cells alleviate the early brain injury of subarachnoid hemorrhage partly by suppression of Notch1-dependent neuroinflammation: involvement of Botch（间充质干细胞减轻蛛网膜下腔出血早期脑损伤）

  416. J Exp Clin Cancer Res. 2019 Jan 10;38(1):14.doi: 10.1186/s13046-018-0985-y.
    Fusobacterium nucleatum promotes chemoresistance to 5-fluorouracil by upregulation of BIRC3 expression in colorectal cancer （有核梭杆菌与直肠癌中5-氟尿嘧啶的化疗抗性）

  417. Development. 2018 Dec 17;145(24):dev170670.doi: 10.1242/dev.170670.The microRNAs let-7 and miR-278 regulate insect metamorphosis and oogenesis by targeting the juvenile hormone early-response gene Krüppel-homolog 1

  418. CNS Neurosci Ther. 2018 Oct;24(10):906-916.doi: 10.1111/cns.12833. Epub 2018 Feb 27.
    Inhibition of Lats1/p‐YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.（大鼠创伤性脑损伤模型中神经元凋亡和神经功能障碍研究）

  419. Mol Imaging Biol. 2018 Oct;20(5):761-770.doi: 10.1007/s11307-018-1180-4.
    Bioluminescence Imaging for Monitoring miR-200c Expression in Breast Cancer Cells and its Effects on Epithelial-Mesenchymal Transition Progress in Living Animals.（mir-200c在乳腺癌细胞上皮间质转化中作用研究）

  420. J Cell Physiol. 2018 Sep;233(9):6615-6631.doi: 10.1002/jcp.26274. Epub 2018 Mar 25.
    miR-34b-5p inhibition attenuates lung inflammation and apoptosis in an LPS-induced acute lung injury mouse model by targeting progranulin （miR‐34b‐5p与急性肺损伤研究）

  421. Cell Death Dis. 2018 Sep 20;9(10):962.doi: 10.1038/s41419-018-1021-z.A miR-125b/CSF1-CX3CL1/tumor-associated macrophage recruitment axis controls testicular germ cell tumor growth

  422. Can J Physiol Pharmacol. 2018 Jun;96(6):611-617.doi: 10.1139/cjpp-2017-0586. Epub 2018 Mar 5.
    The role of microRNA-146a in regulating the expression of IRAK1 in cerebral ischemia-reperfusion injury.（microRNA-146a在调控脑缺血-再灌注损伤中IRAK1表达的作用研究）

  423. Bone. 2018 Jun;111:82-91.doi: 10.1016/j.bone.2018.03.017. Epub 2018 Mar 16.
    Overexpression of DNMT1 leads to hypermethylation of H19 promoter and inhibition of Erk signaling pathway in disuse osteoporosis （DNMT1过表达和废用性骨质疏松研究）

  424. Biomaterials. 2018 May;165:48-55.doi: 10.1016/j.biomaterials.2018.02.045. Epub 2018 Feb 24.
    Hypoxia-inducible Factor-1α directs renal regeneration induced by decellularized scaffolds.（DNA甲基转移酶3a与乙型肝炎病毒研究）

  425. Biofactors.2018 May 24.doi: 10.1002/biof.1433. Online ahead of print. MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/MDM-2/p53 pathway after traumatic spinal cord injury in rats

  426. Neuroscience. 2018 Mar 15;374:214-222.doi: 10.1016/j.neuroscience.2018.01.049. Epub 2018 Feb 5.
    Long Non-coding RNA BC168687 is Involved in TRPV1-mediated Diabetic Neuropathic Pain in Rats.（LncRNA BC168687参与TRPV1受体介导的糖尿病大鼠神经病理性疼痛）

  427. Purinergic Signal. 2018 Mar;14(1):47-58.doi: 10.1007/s11302-017-9594-z. Epub 2017 Nov 20.
    P2Y 12 receptor upregulation in satellite glial cells is involved in neuropathic pain induced by HIV glycoprotein 120 and 2′,3′-dideoxycytidine （卫星胶质细胞中P2Y12受体上调与神经性疼痛研究）

  428. Mol Ther Nucleic Acids. 2018 Mar 2;10:237-244.doi: 10.1016/j.omtn.2017.12.007. Epub 2017 Dec 19.
    Circular siRNAs for Reducing Off-Target Effects and Enhancing Long-Term Gene Silencing in Cells and Mice.（环状siRNA与基因脱靶效应研究）

  429. Neurobiol Dis. 2018 Feb;110:82-92.doi: 10.1016/j.nbd.2017.11.012. Epub 2017 Dec 2.
    Critical role for Annexin A7 in secondary brain injury mediated by its phosphorylation after experimental intracerebral hemorrhage in rats （膜联蛋白A7在大鼠继发性脑损伤中的作用研究）

  430. Front Cell Neurosci. 2018 Jan 11;11:432.doi: 10.3389/fncel.2017.00432. eCollection 2017.
    Neuroprotection Exerted by Netrin-1 and Kinesin Motor KIF1A in Secondary Brain Injury following Experimental Intracerebral Hemorrhage in Rats.（神经轴突导向因子netrin-1与大鼠实验性脑出血后继发性脑损伤中的神经保护作用研究）

  431. Evid Based Complement Alternat Med. 2018 Jan 9;2018:6139372.doi: 10.1155/2018/6139372. eCollection 2018.
    The Protective Effect of Total Flavones from Rhododendron simsii Planch. on Myocardial Ischemia/Reperfusion Injury and Its Underlying Mechanism.（杜鹃花总黄酮对心肌缺血再灌注损伤保护作用）

  432. Cell Death Dis. 2018 Jan 9;9(1):11.doi: 10.1038/s41419-017-0014-7.
    miRNA-3473b contributes to neuroinflammation following cerebral ischemia.（miRNA-3473b导致脑缺血后神经炎症）

  433. Exp Cell Res. 2017 Dec 15;361(2):342-352.doi: 10.1016/j.yexcr.2017.11.002. Epub 2017 Nov 2.
    Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway.（促红细胞生成素与蛛网膜下腔出血早期脑损伤研究）

  434. Cell Death Dis. 2017 Dec 13;8(12):3211.doi: 10.1038/s41419-017-0047-y.
    Long non-coding RNA MEG3 functions as a competing endogenous RNA to regulate ischemic neuronal death by targeting miR-21/PDCD4 signaling pathway （LncRNA MEG3与缺血性神经元死亡研究）

  435. Cell Mol Neurobiol. 2017 Nov;37(8):1457-1464.doi: 10.1007/s10571-017-0476-2. Epub 2017 Feb 25.
    Regulation of Sirtuin 3-Mediated Deacetylation of Cyclophilin D Attenuated Cognitive Dysfunction Induced by Sepsis-Associated Encephalopathy in Mice. （siRNA侧脑室注射研究小鼠脓毒症相关脑病引起的认知功能障碍）

  436. Chem Sci. 2017 Oct 19;9(1):44-51.doi: 10.1039/c7sc03842a. eCollection 2018 Jan 7.
    Caged circular siRNAs for photomodulation of gene expression in cells and mice （环状RNA与基因表达光调控）

  437. Neurol Res. 2017 Sep;39(9):795-802.doi: 10.1080/01616412.2017.1321710. Epub 2017 May 1.
    The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains.（15-LO-1siRNA通过在小鼠缺血性脑中上调VEGF来促进血管生成）

  438. J Neurochem. 2017 Aug;142(3):478-492.doi: 10.1111/jnc.14075. Epub 2017 Jun 20.
    Tumor necrosis factor receptor-associated factor 6 participates in early brain injury after subarachnoid hemorrhage in rats through inhibiting autophagy and promoting oxidative stress （大鼠蛛网膜下腔出血与早期脑损伤）

  439. Biochem Biophys Res Commun. 2017 Aug 5;489(4):386-392.doi: 10.1016/j.bbrc.2017.05.136. Epub 2017 May 25.
    Targeting long non-coding RNA ASBEL with oligonucleotide antagonist for breast cancer therapy （长链非编码RNA与乳腺癌治疗）

  440. Mediators Inflamm. 2017;2017:1570917.doi: 10.1155/2017/1570917. Epub 2017 Feb 15.
    Involvement of Toll Like Receptor 2 Signaling in Secondary Injury during Experimental Diffuse Axonal Injury in Rats. （大鼠实验性弥漫性轴索损伤）

  441. EBioMedicine. 2017 May;19:49-59.doi: 10.1016/j.ebiom.2017.04.017. Epub 2017 Apr 11.
    Fluvastatin Prevents Lung Adenocarcinoma Bone Metastasis by Triggering Autophagy.（siRNA与小鼠肺腺癌骨转移研究）

  442. Clin Exp Pharmacol Physiol. 2017 Jun;44(6):656-663.doi: 10.1111/1440-1681.12742.
    Limb remote ischaemic postconditioning-induced elevation of fibulin-5 confers neuroprotection to rats with cerebral ischaemia/reperfusion injury: Activation of the AKT pathway （AKT通路与大鼠大脑局部缺血/再灌注损伤）

  443. Blood. 2017 Jun 15;129(24):3196-3209.doi: 10.1182/blood-2016-11-749838. Epub 2017 Apr 27. (IF:11.841). Osteoblasts support megakaryopoiesis through production of interleukin 9.（成骨细胞与白介素9研究）

  444. Oncotarget. 2017 May 30;8(47):82064-82077.doi: 10.18632/oncotarget.18289. eCollection 2017 Oct 10. (IF:5.168).
    MicroRNA-423-5p facilitates hypoxia/reoxygenation-induced apoptosis in renal proximal tubular epithelial cells by targeting GSTM1 via endoplasmic reticulum stress （肾小管上皮细胞凋亡）

  445. Can J Physiol Pharmacol. 2017 Apr;95(4):437-442.doi: 10.1139/cjpp-2016-0248. Epub 2016 Nov 24.
    miR-29b promotes skin wound healing and reduces excessive scar formation by inhibition of TGF-β1/Smad/CTGF signaling pathway.（miR-29b通过抑制TGF-β1/ Smad / CTGF信号通路促进皮肤伤口愈合并减少过度瘢痕形成）

  446. J Bone Miner Res. 2017 Feb;32(2):319-332.doi: 10.1002/jbmr.2992. Epub 2017 Jan 3.(IF:5.622).
    TET3 Mediates Alterations in the Epigenetic Marker 5hmC and Akt pathway in Steroid-Associated Osteonecrosis （TET3介导类固醇相关性骨坏死中表观遗传标记5hmC和Akt途径的改变）

  447. Exp Ther Med. 2016 Dec;12(6):4121-4127.doi: 10.3892/etm.2016.3900. Epub 2016 Nov 14.
    Role of miR-145 in chronic constriction injury in rats.(miR-145在大鼠慢性压迫性损伤中的作用）

  448. Int Immunopharmacol. 2016 Nov;40:339-346.doi: 10.1016/j.intimp.2016.09.011. Epub 2016 Sep 24.
    Fine-tuning the expression of microRNA-155 controls acetaminophen-induced liver inflammation（miR-155与乙酰氨基酚诱导的肝脏炎症）

  449. Genet Test Mol Biomarkers. 2016 Nov;20(11):645-653.doi: 10.1089/gtmb.2016.0011. Epub 2016 Sep 27.
    Upregulation of miR-98 Inhibits Apoptosis in Cartilage Cells in Osteoarthritis.（miR-98上调可抑制骨关节炎中软骨细胞凋亡）

  450. J Cell Sci. 2016 Nov 15;129(22):4305-4316.doi: 10.1242/jcs.189944. Epub 2016 Sep 26. (IF:5.168).
    HMGB2 regulates satellite-cell-mediated skeletal muscle regeneration through IGF2BP2 （HMGB2通过IGF2BP2调节卫星细胞介导的骨骼肌再生）

  451. Exp Eye Res. 2016 Oct;151:134-41.doi: 10.1016/j.exer.2016.08.010. Epub 2016 Aug 25.
    CD25 siRNA induces Treg/Th1 cytokine expression in rat corneal transplantation models( CD25 siRNA诱导大鼠角膜移植模型中的Treg / Th1细胞因子表达）

  452. Arthritis Rheumatol. 2016 Sep;68(9):2232-43.doi: 10.1002/art.39725. (IF:6.009).
    MiR-130b ameliorates murine lupus nephritis through targeting type I interferon pathway on resident renal cells.（miR-130b通过靶向I型干扰素通路作用于肾脏固有细胞从而改善小鼠狼疮性肾）

  453. J Cardiovasc Pharmacol Ther. 2016 Sep;21(5):471-7.doi: 10.1177/1074248415624158. Epub 2016 Feb 4.
    The PTEN/Akt Signaling Pathway Mediates Myocardial Apoptosis in Swine After Coronary Microembolization(PTEN / Akt信号通路介导猪冠状动脉微栓塞后心肌细胞凋亡)

  454. Int J Clin Exp Pathol 2016;9(3):3125-3133
    Original Article Regulation of ZNF580 in pathogenesis of ischemic cerebrovascular disease accompanied with upregulation of Smad2 and ADNP( 在伴随着Smad2和ADNP上调缺血性脑血管病的发病机制中ZNF580的调节）

  455. Sci Rep. 2016 Sep 19;6:33577.doi: 10.1038/srep33577. (IF:5.228).
    Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.（蛛网膜下腔出血和小鼠大脑损伤）

  456. Cell Physiol Biochem. 2016;38(1):207-19.doi: 10.1159/000438622. Epub 2016 Jan 20.
    Atorvastatin Inhibits Myocardial Apoptosis in a Swine Model of Coronary Microembolization by Regulating PTEN/PI3K/Akt Signaling Pathway.（阿托伐他汀通过调节PTEN/PI3K/Akt信号通路抑制冠状动脉微栓塞模型猪心肌细胞凋亡）

  457. Cell Physiol Biochem. 2016;38(2):836-46.doi: 10.1159/000443038. Epub 2016 Feb 24.
    Upregulation of Long Non-Coding RNA PlncRNA-1 Promotes Metastasis and Induces Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma.(长链非编码RNA PlncRNA-1的上调可以促进并诱导肝癌细胞上皮间质之间转化）

  458. Int J Mol Med. 2016 Jul;38(1):113-22.doi: 10.3892/ijmm.2016.2619. Epub 2016 May 31.
    miR-1 suppresses the growth of esophageal squamous cell carcinoma in vivo and in vitro through the downregulation of MET, cyclin D1 and CDK4 expression.（miR-1通过MET，细胞周期蛋白D1和CDK4表达的下调在体内和体外抑制食管鳞状细胞癌的生长）

  459. Int J Biochem Cell Biol. 2016 Jun;75:11-22.doi: 10.1016/j.biocel.2016.03.008. Epub 2016 Mar 18.
    Inhibitory effects of omega-3 fatty acids on early brain injury after subarachnoid hemorrhage in rats: Possible involvement of G protein-coupled receptor 120/β-arrestin2/TGF-βactivated kinase-1 binding protein-1 signaling pathway.（ω-3脂肪酸对大鼠蛛网膜下腔出血早期脑损伤的抑制作用）

  460. Oncotarget. 2016 Jun 14;7(24):37192-37204.doi: 10.18632/oncotarget.9293.
    Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine （抑制Bmi1可以增强胰腺癌细胞对gemcitabine的敏感性）

  461. Sci Rep. 2016 Jun 29;6:28776.doi: 10.1038/srep28776. (IF:5.228).
    Molecular characterization of woodchuck IFI16 and AIM2 and their expression in woodchucks infected with woodchuck hepatitis virus (WHV) （土拨鼠肝炎病毒感染的土拨鼠中IFI16和AIM2的分子鉴定及表达）

  462. Chinese Journal of Biochemistry and Molecular Biology. 2016 Jun 9.
    过表达微小RNA miR-125b抑制肝癌细胞上皮-间质转换及促进细胞凋亡

  463. Am J Cancer Res. 2016 Jun 1;6(6):1302-16.eCollection 2016.
    BMPR2-pSMAD1/5 signaling pathway regulates RUNX2 expression and impacts the progression of dedifferentiated chondrosarcoma （BMPR2-pSMAD1 / 5信号通路调节RUNX2表达，并影响去分化软骨肉瘤的进展）

  464. Arthritis Rheumatol. 2016 Apr;68(4):953-64.doi: 10.1002/art.39485. (IF:6.009).
    In Vivo Therapeutic Success of MicroRNA‐155 (miR‐155) Antagomir in a Mouse Model of Lupus Alveolar Hemorrhage.(miR‐155拮抗剂体内成功治疗狼疮性肺泡出血模型的小鼠）

  465. Mol Brain. 2016 Apr 23;9:44.doi: 10.1186/s13041-016-0226-2.
    LncRNA NONRATT021972 siRNA regulates neuropathic pain behaviors in type 2 diabetic rats through the P2X7 receptor in dorsal root ganglia.（长链非编码RNA NONRATT021972 干扰RNA可通过作用于背根神经节P2X7受体调节2型糖尿病大鼠神经性疼痛的行为）

  466. Med Sci Monit. 2016 Apr 7;22:1161-70.doi: 10.12659/msm.897909.
    MiR-206 Attenuates Denervation-Induced Skeletal Muscle Atrophy in Rats Through Regulation of Satellite Cell Differentiation via TGF-β1, Smad3, and HDAC4 Signaling.(miR-206通过TGF-β1、Smad3和HDAC4信号调控卫星细胞分化进而减弱大鼠骨骼肌萎缩）

  467. J Cardiovasc Pharmacol Ther. 2016 Mar;21(2):209-18.doi: 10.1177/1074248415599265. Epub 2015 Aug 14.
    Coronary Microembolization Induces Cardiomyocyte Apoptosis in Swine by Activating the LOX-1-Dependent Mitochondrial Pathway and Caspase-8-Dependent Pathway.（冠状动脉微栓塞可通过激活lox-1依赖型线粒体通路和半胱天冬酶-8依赖型通路引起猪的心肌细胞凋亡）

  468. Cell Death Dis. 2016 Mar 24;7(3):e2151.doi: 10.1038/cddis.2016.56.
    Inhibition of glycogen synthase kinase 3β promotes autophagy to protect mice from acute liver failure mediated by peroxisome proliferator-activated receptor α.（抑制糖原合成酶激酶3β可以促进自噬以保护小鼠免受由过氧化物酶体增殖物激活受体介导的急性肝衰竭的的损害）

  469. J Exp Clin Cancer Res. 2016 Mar 11;35:44.doi: 10.1186/s13046-016-0321-3.
    Inhibition of SOX2 induces cell apoptosis and G1/S arrest in Ewing’s sarcoma through the PI3K/Akt pathway(PI3K/Akt 信号通路中SOX2基因的抑制可以诱导尤文肉瘤细胞凋亡及G1/S的捕捉）

  470. PLoS One. 2016 Mar 9;11(3):e0149257.doi: 10.1371/journal.pone.0149257. eCollection 2016.
    MiR-3162-3p Is a Novel MicroRNA That Exacerbates Asthma by Regulating β-Catenin.( MiR-3162-3p通过调控β-链蛋白从而加剧哮喘的发作)

  471. Eur J Pharmacol. 2016 Jan 15;771:241-6.doi: 10.1016/j.ejphar.2015.11.051. Epub 2015 Dec 4.
    Effect of vasopressin on Na(+)-K(+)-2Cl(-) cotransporter (NKCC) and the signaling mechanisms on the murine late distal colon.（抗利尿激素对Na(+)-K(+)-2Cl(-) 协同转运蛋白的作用以及对小鼠远端结肠的信号机制）

  472. Cell Mol Life Sci. 2015 Dec;72(24):4849-66.doi: 10.1007/s00018-015-1973-4. Epub 2015 Jun 26. (IF:5.808).
    Rab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium.(肺微血管内皮细胞)

  473. Endocrinology. 2015 Nov;156(11):4244-56.doi: 10.1210/en.2015-1217. Epub 2015 Sep 11.
    Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.(雷帕霉素靶蛋白不敏感组分(Rictor)通过控制小鼠睾丸支持细胞骨架的组织和细胞极性调节精子发生)

  474. Brain Behav Immun. 2015 Oct;49:75-85.doi: 10.1016/j.bbi.2015.04.014. Epub 2015 Apr 29. (IF:5.889).
    MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation.(MicroRNA let-7c-5p通过抑制小胶质细胞活化防止脑缺血损伤)

  475. Graefes Arch Clin Exp Ophthalmol. 2015 Oct;253(10):1765-76.doi: 10.1007/s00417-015-3067-2. Epub 2015 May 31.
    Effects of CD25siRNAgene transfer on high-risk rat corneal graft rejection.(高危大鼠角膜移植片排斥中CD25siRNA基因转移作用)

  476. Crit Care Med. 2015 Sep;43(9):e369-81.doi: 10.1097/CCM.0000000000001146.
    Cyclophilin A/Cluster of Differentiation 147 Interactions Participate in Early Brain Injury After Subarachnoid Hemorrhage in Rats.(大鼠蛛网膜下腔出血早期亲环蛋白A/CD147相互作用) (IF:7.422).

  477. Hepatology. 2015 Sep;62(3):801-15.doi: 10.1002/hep.27887. Epub 2015 Jul 3.
    MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4.(（MicroRNA-125b通过small mothers减少Dpp2和4以减弱上皮细胞-间充质细胞转化并作用于肝癌细胞干细胞）(IF:11.711).

  478. Endocrine. 2015 Aug;49(3):752-60.doi: 10.1007/s12020-015-0546-5. Epub 2015 Feb 11.
    MiR-346 regulates CD4+CXCR5 + T cells in the pathogenesis of Graves’ disease.(甲状腺)

  479. Oncotarget. 2015 Apr 20;6(11):8900-13.doi: 10.18632/oncotarget.3561.
    Macrophages promote benzopyrene-induced tumor transformation of human bronchial epithelial cells by activation of NF-κB and STAT3 signaling in a bionic airway chip culture and in animal models.（巨噬细胞通过在仿生气道芯片培养和动物模型的κB和STAT3信号通路的活化从而促进苯并芘诱导的人支气管上皮细胞肿瘤的转化)(IF:5.168).

  480. Basic Res Cardiol. 2015 May;110(3):28.doi: 10.1007/s00395-015-0484-7. Epub 2015 Apr 10. (IF:6.038).
    Sialyltransferase7A, a Klf4-responsive gene, promotes cardiomyocyte apoptosis during myocardial infarction.(Sialyltransferase7A，一个Klf4的应答基因，在心肌梗死中促进心肌细胞凋亡)(IF:8.058).

  481. PLoS One. 2015 Mar 20;10(3):e0120046.doi: 10.1371/journal.pone.0120046. eCollection 2015.
    ENTPD5 Induces Apoptosis in Lung Cancer Cells via Regulating Caspase 3 Expression.(ENTPD5通过调控Caspase 3表达诱导肺癌细胞凋亡)

  482. Cancer Res. 2015 Mar 15;75(6):1080-90.doi: 10.1158/0008-5472.CAN-14-1831. Epub 2015 Jan 19. (IF:9.329).
    Targeting LunX inhibits non-small-cell lung cancer growth and metastasis.(肺癌)

  483. Exp Biol Med (Maywood). 2015 Nov;240(11):1426-33.doi: 10.1177/1535370215573400. Epub 2015 Mar 13.
    Mechanism of programmed cell death factor 4/nuclear factor-κB signaling pathway in porcine coronary micro-embolization-induced cardiac dysfunction.细胞死亡因子4/NF-κB在猪冠状动脉微栓塞引起的心脏功能障碍中的发生机制)

  484. J Neuroinflammation. 2015 Jan 28;12:18.doi: 10.1186/s12974-014-0233-0. (IF:5.408).
    NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model.NLRP1(炎性体在内侧颞叶癫痫患者中被激活并能促进在杏仁核刺激的大鼠模型的神经元细胞死亡)

  485. Cell Death Dis. 2014 Dec 11;5(12):e1571.doi: 10.1038/cddis.2014.540. (IF:5.014).
    BMPR2 inhibition induced apoptosis and autophagy via destabilization of XIAP in human chondrosarcoma cells.(软骨肉瘤相关，siRNA皮下肿瘤注射)

  486. Mol Cancer. 2014 Sep 6;13:206.doi: 10.1186/1476-4598-13-206. Let-7d suppresses growth, metastasis, and tumor macrophage infiltration in renal cell carcinoma by targeting COL3A1 and CCL7.(Let-7d通过靶向COL3A1和CCL7抑制肾细胞癌的生长、转移和肿瘤巨噬细胞浸润)(IF:37.3).

  487. Cell Death Dis. 2014 Aug 21;5(8):e1382.doi: 10.1038/cddis.2014.348.
    Amyloid-β induces NLRP1-dependent neuronal pyroptosis in models of Alzheimer’s disease.(阿尔茨海默病)(IF:5.014).

  488. J Alzheimers Dis. 2014;38(3):633-46.doi: 10.3233/JAD-131148.
    IL12/23 p40 Inhibition Ameliorates Alzheimer’s Disease-Associated Neuropathology and Spatial Memory in SAMP8 Mice.(脑室注射siRNA研究对阿耳茨海默氏病的治疗)

  489. Mol Immunol. 2014 May;59(1):30-8.doi: 10.1016/j.molimm.2013.12.004. Epub 2014 Jan 22.
    Inhibition of IL-2 inducible T-cell kinase alleviates T-cell activation and murine myocardial inflammation associated with CVB3 infection.(心脏疾病)

  490. Neurosci Lett. 2014 Apr 30;566:298-303.doi: 10.1016/j.neulet.2014.02.066. Epub 2014 Mar 12.
    Autophagic effect of programmed cell death 5 (PDCD5) after focal cerebral ischemic reperfusion injury in rats.(凋亡相关研究)

  491. Biomed Res Int. 2014;2014:898646.doi: 10.1155/2014/898646. Epub 2014 Jun 26.
    Trichinella spiralis excretory-secretory products protect against polymicrobial sepsis by suppressing MyD88 via mannose receptor.(免疫系统)

  492. J Neuroimmunol. 2014 Jan 15;266(1-2):56-63.doi: 10.1016/j.jneuroim.2013.09.019. Epub 2013 Oct 8.
    MicroRNA-155 Modulates Th1 and Th17 Cell Differentiation and is Associated with Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.(注射miRNA研究对免疫疾病的作用机理)

  493. J Neuroimmunol. 2014 Jan 15;266(1-2):56-63.doi: 10.1016/j.jneuroim.2013.09.019. Epub 2013 Oct 8.
    MicroRNA-155 Modulates Th1 and Th17 Cell Differentiation and is Associated with Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis.(注射miRNA研究对免疫疾病的作用机理)

  494. J Biol Chem. 2013 Nov 29;288(48):34612-26.doi: 10.1074/jbc.M113.494369. Epub 2013 Oct 4.
    Heme Oxygenase-1 Exerts a Protective Role in Ovalbumin-induced Neutrophilic Airway Inflammation by Inhibiting Response in the Immune Cells Th17.(肺过敏性哮喘)

  495. Int J Nanomedicine . 2013;8:3805-16. doi: 10.2147/IJN.S48950. Epub 2013 Oct 2. Efficacy and safety of dendrimer nanoparticles with coexpression of tumor necrosis factor-α and herpes simplex virus thymidine kinase in gene radiotherapy of the human uveal melanoma OCM-1 cell line. (IF:6.400).

  496. Purinergic Signal. 2013 Sep;9(3):463-79.doi: 10.1007/s11302-013-9367-2. Epub 2013 Jun 11.
    Sensory-sympathetic coupling in superior cervical ganglia after myocardial ischemic injury facilitates sympathoexcitatory action via P2X7 receptor.(舌下静脉注射siRNA干扰脊神经背根神经节受体)

  497. CNS Neurosci Ther. 2013 Aug;19(8):566-76.doi: 10.1111/cns.12114. Epub 2013 May 3.
    The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.(脑室注射siRNA研究脑缺血的凋亡机理)

  498. Curr Pharm Des. 2013;19(7):1242-52.doi: 10.2174/138161213804805739.
    MicroRNAs (miRNAs) in colorectal cancer: From aberrant expression towards therapy.

  499. Matrix Biol. 2013 Jun 24;32(5):265-76.doi: 10.1016/j.matbio.2013.02.004. Epub 2013 Mar 5. (IF:5.074).
    Transdermal siRNA-TGFβ1-337 patch for hypertrophic scar treatment.(皮肤涂抹siRNA研究治疗皮肤瘢痕)

  500. J Cereb Blood Flow Metab. 2013 Mar;33(3):396-406.doi: 10.1038/jcbfm.2012.179. Epub 2013 Jan 9. (IF:5.407).
    SirT1 mediates hyperbaric oxygen preconditioning-induced ischemic tolerance in rat brain. (脑室注射siRNA研究脑缺血机理)

  501. Cancer Lett. 2012 Jan 28;314(2):223-31.doi: 10.1016/j.canlet.2011.09.033. Epub 2011 Oct 5. (IF:5.621).
    Epub 2011 Oct 5.NIRF is frequently upregulated in colorectal cancer and its oncogenicity can be suppressed by let-7a microRNA.(皮下肿瘤注射miRNA研究治疗结肠癌)

  502. Progress in Modern Biomedicine. 2010 Sep.
    Anti-Virus Research on Short Double-Stranded RNA in Mouse Models with Viral Myocarditis.

应用本产品文献

  1. Entranster™系列转染试剂的成分和原理，化学结构，粒径，电位等数据

  2. siRNA转染后什么时候做qRT-PCR最好？ siRNA转染后什么时候做蛋白检测检测最好？

  3. siRNA转染与DNA转染有什么不一样?

  4. 成功siRNA转染的主要关键点有什么？

  5. 体内转染常见问题

  6. 体内转染和病毒感染的比较

  7. 转基因动物/基因敲除动物与体内转染的比较

  8. 小鼠尾静脉注射技巧

相关问题

运输与储存

常温运输，于4℃长期存储，有效期12个月。

质量保证

北京英格恩生物科技有限公司本产品实行严格质量检验，并进行转染验证，以确保产品质量。请用户使用前务必认真阅读操作手册。如用户仍然有问题，请立即联系本公司人员，英格恩公司将负责提供全程技术服务。

使用限制

本品仅限科研用途。

常见问题

体内转染 in vivo 能把哪些核酸导入动物体内?

专用于动物体内转染,可将 siRNA、miRNA、mimic、inhibitor 等小片断 RNA 直接送入动物体内,用于 RNA 干扰、基因治疗和蛋白功能的体内研究。

体内转染 in vivo 支持哪些给药途径?

可经尾静脉注射进行全身递送,也可对各器官局部注射。

体内转染 in vivo 相比病毒载体有什么优势?

它不是病毒、也非脂质体,采用纳米技术合成,能保护并浓缩核酸、避免其被体液破坏,对动物无明显炎性反应;无需病毒包装,注射后一般 12-48 小时可检测效果。

体内转染 in vivo 怎么操作?剂量怎么参考?

只需将核酸与转染试剂分别稀释后混合注射;同系列说明书中,siRNA 尾静脉给药推荐剂量为 2.5-5 mg/kg(起始 2.5 mg/kg)。

体内转染 in vivo 如何运输储存?有效期和规格是什么?

常温运输,到货后 4℃ 长期保存,有效期 12 个月;规格为 1ml(货号 18668-11),仅限科研用途。

体内转染 in vivo 三款(通用/DNA/RNA)怎么选?

英格恩体内转染试剂按核酸选:体内递送质粒 DNA 做蛋白表达用 DNA 体内转染;体内递送 siRNA、miRNA 等小 RNA 做基因沉默用 RNA 体内转染;通用 in vivo 适用于小 RNA 的体内递送。

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