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Members of the miR-30 family inhibit the epithelial-to-mesenchymal transition of non-small-cell lung cancer cells by suppressing XB130 expression levels

Kewei Song  ¹ , Yinhui Jiang  ^{1   2} , Yan Zhao  ^{1   2} , Yuan Xie  ^{1   2} , Jianjiang Zhou  ^{1   2} , Wenfeng Yu  ^{1   2} , Qinrong Wang  ^{1   2} Affiliations

• PMID: 32863901
• PMCID: PMC7436119
• DOI: 10.3892/ol.2020.11929

Free PMC article

Abstract

MicroRNAs (miRs) are associated with cancer metastasis. Aberrant expression levels of members of the miR-30 family have been observed in non-small-cell lung cancer (NSCLC). However, the effects of miR-30 family members on the epithelial-to-mesenchymal transition (EMT) of NSCLC cells and the underlying molecular mechanisms have not yet been fully elucidated. The present study investigated the effects of miR-30 family members on EMT, migration and invasion of NSCLC cells and found that overexpression of these miRs inhibited EMT via decreasing the expression levels of N-cadherin, β-catenin and SNAI1, along with weakened migration and invasion abilities. Then, XB130 was identified as a downstream target of the miR-30 family members. XB130-knockdown also inhibited EMT of NSCLC cells, whereas ectopic overexpression of XB130 partly rescued the suppressive effects of miR-30c and miR-30d on EMT. In conclusion, miR-30 family members inhibited EMT of NSCLC cells, partially via suppressing XB130 expression levels.

Keywords: XB130; epithelial-to-mesenchymal transition; invasion; miR-30 family; migration; non-small cell lung cancer.